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. 2001 Dec;5(6):494-6.
doi: 10.1046/j.1526-0968.2001.00386.x.

Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes

H Goto  1 , H Matsuo, S Nakane, H Izumoto, T Fukudome, C Kambara, N Shibuya
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Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes

H Goto et al. Ther Apher. 2001 Dec.

Abstract

Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immunoadsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.

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