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. 2002 Jan 28;88(4):048101.
doi: 10.1103/PhysRevLett.88.048101. Epub 2002 Jan 8.

Epigenetics as a first exit problem

E Aurell  1 , K Sneppen
Affiliations

Epigenetics as a first exit problem

E Aurell et al. Phys Rev Lett. .

Abstract

We develop a framework to discuss the stability of epigenetic states as first exit problems in dynamical systems with noise. We consider in particular the stability of the lysogenic state of the lambda prophage. The formalism defines a quantitative measure of robustness of inherited states.

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