Comparative Study
doi: 10.1007/BF02027159.
Effect of single and multiple treatments with phenylbutazone in normal and adjuvant-induced polyarthritic rats
- PMID: 1180177
- DOI: 10.1007/BF02027159
Item in Clipboard
Comparative Study
Effect of single and multiple treatments with phenylbutazone in normal and adjuvant-induced polyarthritic rats
Agents Actions.
1975 Feb.
Abstract
Liver function alterations, in the adjuvant induced polyarthritis procedure in rats, has been demonstrated by many investigators. We observed a significant inhibition of the polyarthritis with phenylbutazone but we were unable to find any changes in the relative liver weights of SGPT, AP or BUN in polyarthritic or phenylbutazone treated rats. However, we did observe that polyarthritic rats maintained a significantly higher plasma phenylbutazone concentration than the corresponding non-arthritic controls. This appears to futher substantiate the influence of 'pathopharmacodynamics' on the disposition and activity of drugs.
Similar articles
-
Effects of multiple treatments of isoxicam on organ weights and serum SGPT, AP, and BUN in adjuvant-induced polyarthritic rats.Res Commun Chem Pathol Pharmacol. 1978 Mar;19(3):529-32. Res Commun Chem Pathol Pharmacol. 1978. PMID: 653106
-
Influence of nonsteroidal antirheumatic drugs on collagen metabolism in rats with adjuvant-induced arthritis.Pharmacology. 1974;12(2):110-6. doi: 10.1159/000136528. Pharmacology. 1974. PMID: 4431833 No abstract available.
-
Phenylbutazone: plasma concentrations and effectiveness in patients with rheumatoid arthritis.J Int Med Res. 1977;5 Suppl 2:40-7. J Int Med Res. 1977. PMID: 913873 Clinical Trial.
-
The effect of acetylsalicylic acid, phenylbutazone and indomethacin on the binding of 11-hydroxysteroids to plasma proteins in patients with rheumatoid arthritis.J Pharm Pharmacol. 1968 Dec;20:Suppl:248S+. doi: 10.1111/j.2042-7158.1968.tb09890.x. J Pharm Pharmacol. 1968. PMID: 4388166 No abstract available.
-
[On the effect of phenylbutazone on the thrombotic syndrome].Z Gesamte Inn Med. 1968 Nov 15;23(22):728-9. Z Gesamte Inn Med. 1968. PMID: 5729123 German. No abstract available.
Cited by
-
Anti-inflammatory activity of isoxicam in combination with aspirin or D-propoxyphene.Agents Actions. 1976 Nov;6(6):748-54. doi: 10.1007/BF02026098. Agents Actions. 1976. PMID: 1008020
-
Depression of drug metabolism in the mouse by a combination of Mycobacterium butyricum and anaesthetics.Br J Pharmacol. 1979 Jan;65(1):111-5. doi: 10.1111/j.1476-5381.1979.tb17339.x. Br J Pharmacol. 1979. PMID: 760885 Free PMC article.