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Review
. 2001 Dec;3(6):554-66.

Beta2-adrenergic receptor genetics

B A Raby  1 , S T Weiss
Affiliations
  • PMID: 11804270
Review

Beta2-adrenergic receptor genetics

B A Raby et al. Curr Opin Mol Ther. 2001 Dec.

Abstract

The beta2-adrenergic receptor (beta2AR) is a positional candidate gene for asthma located on 5q31-33. There are 17 known polymorphisms in this gene. A determination of the functional significance of these polymorphisms is complicated by the lack of haplotypic assessment in most functional assays. The beta2AR gene is not an asthma-susceptibility gene but appears to be a minor determinant for lung function. The gene also has clear pharmacogenetic effects. Further work is needed to fully define the effects of haplotype on function, disease phenotype and pharmacogenetic effect.

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