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. 2002 Jan 30;124(4):520-1.
doi: 10.1021/ja017277z.

Total synthesis of ustiloxin D

Bin Cao  1 , Haengsoon Park, Madeleine M Joullié
Affiliations

Total synthesis of ustiloxin D

Bin Cao et al. J Am Chem Soc. .

Abstract

The total synthesis of ustiloxin D, a highly potent inhibitor of microtubule assembly, has been achieved. Notable features are the use of nucleophilic aromatic substitution (SNAr) for the construction of a chiral tertiary alkyl-aryl ether linkage, Sharpless asymmetric aminohydroxylation for the formation of the beta-hydroxytyrosine moiety, macrolactamization, and regioselective methylation.

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