[Action of valinomycin in vivo on Ehrlich ascites tumor cells. A change in the ultrastructure of the tumor cells under the influence of valinomycin]
[Article in
Russian]
- PMID: 1180536
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[Action of valinomycin in vivo on Ehrlich ascites tumor cells. A change in the ultrastructure of the tumor cells under the influence of valinomycin]
[Article in
Russian]
Antibiotiki.
1975 Sep.
Abstract
It was found with the help of electron microscopy that valinomycin administered to mice with Ehrlich ascitic tumors in a dose inhibiting the proliferating activity induced impairements in the mitochondria. The changes were similar to those under the effect of valinomycin in vitro. An increase in the antibiotic dose resulted in more pronounced and irreversible changes not only in the mitochondria but also in other structures of the tumor cells.
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