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Review
. 2002;3(1):6.
doi: 10.1186/rr178. Epub 2001 Oct 25.

Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis

Ulrike Seitzer  1 , Johannes Gerdes, Joachim Müller-Quernheim
Affiliations
Review

Genotyping in the MHC locus: potential for defining predictive markers in sarcoidosis

Ulrike Seitzer et al. Respir Res. 2002.

Abstract

In sarcoidosis, host genetic factors are discussed as contributing to disease susceptibility and course. Since tumor necrosis factor (TNF)-alpha is a central mediator of granuloma formation and since elevated TNF-alpha levels are found during active phases of sarcoidosis, genetic polymorphisms correlating with influences on TNF-alpha levels are of special interest. The complete sequencing of the MHC region and the increase in the number of identified gene polymorphisms in this locus associated with TNF-alpha production offer the opportunity of detecting new genes associated with sarcoidosis and perhaps of defining disease-associated haplotypes that bear the potential of serving as predictive markers for this disease.

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