Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2001 Dec;18(12):655-9.
doi: 10.1023/a:1013115301159.

The effect of single-dose oxytocin application on time to ejaculation and seminal parameters in men

K Walch  1 , R Eder, A Schindler, W Feichtinger
Affiliations
Clinical Trial

The effect of single-dose oxytocin application on time to ejaculation and seminal parameters in men

K Walch et al. J Assist Reprod Genet. 2001 Dec.

Abstract

Purpose: To report the effect of a single dose of oxytocin on ejaculation time and seminal parameters.

Methods: The prospective randomized clinical study was performed at a private assisted reproduction technology center and included 103 consecutive healthy men (semen donors or husbands of IVF patients). Oxytocin (16 IU) were administered intranasally to 49 subjects, randomly assigned to the study group just before masturbation to ejaculation. The time needed for ejaculation as well as the semen parameters was recorded according to the WHO standards, and compared to the control group of 54 subjects with no prior oxytocin treatment.

Results: No significant difference was noted between the two groups concerning ejaculation time and semen parameters.

Conclusions: Although the administration of oxytocin stimulates sexual behavior and performance in mammalian species, our data indicate that oxytocin has no detectable effect on ejaculation time and seminal parameters after intranasal application in normal, healthy men.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bruins J, Hijman R, Van Ree JM. Effect of a single dose of Des-Glycinamide-(Arg8)vasopressin or oxytocin on cognitive processes in young healthy subjects. Peptides. 1992;133:461–468. - PubMed
    1. Pitman RK, Orr SP, Lasko B. Effects of intranasal vasopressin and oxytocin on physiologic responding during personal combat imagery in Vietnam veterans with posttraumatic stress disorder. Psychiatry Res. 1993;48:107–117. - PubMed
    1. Pedersen CA, Ascher YL, Monroe YL, Prange AJ. Oxytocin induces maternal behaviour in vergin female rats. Science. 1982;216:648. - PubMed
    1. Stoneham MD, Everitt BJ, Hansen S, Lightman SL, Todd K. Oxytocin and sexual behaviour in the male rat and rabbit. J. Endocrinol. 1995;107(1):97–106. - PubMed
    1. Arletti R, Benelli A, Bertolini A. Sexual behaviour of aging male rats is stimulated by oxytocin. Eur J Pharmacol. 1990;179(3):377–381. - PubMed

Publication types