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. 2002 Jan;65(1):85-8.
doi: 10.1021/np0101705.

Indole and beta-carboline alkaloids from Geissospermum sericeum

Jonathan C P Steele  1 , Nigel C Veitch, Geoffrey C Kite, Monique S J Simmonds, David C Warhurst
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Indole and beta-carboline alkaloids from Geissospermum sericeum

Jonathan C P Steele et al. J Nat Prod. 2002 Jan.

Abstract

The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N(4)-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line.

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