doi: 10.1016/0005-2795(75)90106-3.
Characterization of the collagen of human hypertrophic and normal scars
- PMID: 1180964
- DOI: 10.1016/0005-2795(75)90106-3
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Characterization of the collagen of human hypertrophic and normal scars
Biochim Biophys Acta.
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Abstract
The collagen produced in response to an injury of human skin is initially stabilized by a cross-link derived from hydroxyallysine, and characteristic of embryonic skin. In normal healing there is a change over with time to the cross-link derived from allysine, which is typical of young skin collagen. In contrast, hypertrophic scars fail to follow the time-related changes of normal skin, but retain the characteristics of embryonic collagen, indicating a continued rapid turnover of the collagen. This is further supported by the high proportion of the embryonic Type III collagen present in hypertrophic scars.
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