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. 2002 Feb;3(2):189-95.
doi: 10.1038/ni757. Epub 2002 Jan 22.

CD94-NKG2A receptors regulate antiviral CD8(+) T cell responses

Janice M Moser  1 , James Gibbs, Peter E Jensen, Aron E Lukacher
Affiliations

CD94-NKG2A receptors regulate antiviral CD8(+) T cell responses

Janice M Moser et al. Nat Immunol. 2002 Feb.

Abstract

CD8(+) T lymphocytes mediate immunosurveillance against persistent virus infections and virus-induced neoplasia. Polyoma virus, a highly oncogenic natural mouse DNA virus, establishes persistent infection, but only a few mice are highly susceptible to tumors induced by the virus. Mature antiviral CD8(+) T cells expand in tumor-susceptible mice, but their cytotoxic effector activity is nonfunctional in vivo. Here we show that the natural killer cell inhibitory receptor, CD94-NKG2A, is up-regulated by antiviral CD8(+) T cells during acute polyoma infection and is responsible for down-regulating their antigen-specific cytotoxicity during both viral clearance and virus-induced oncogenesis.

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Comment in

  • Tumor viral escape from inhibited T cells.
    Welsh RM, Stepp SE, Szomolanyi-Tsuda E, Peacock CD. Welsh RM, et al. Nat Immunol. 2002 Feb;3(2):112-4. doi: 10.1038/ni0202-112. Nat Immunol. 2002. PMID: 11812984 No abstract available.

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