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Review
. 2002 Feb;25(2):71-4.
doi: 10.1016/s0166-2236(02)02034-9.

Combinatorial RNAi: a method for evaluating the functions of gene families in Drosophila

Aloisia Schmid  1 , Benno Schindelholz, Kai Zinn
Affiliations
Review

Combinatorial RNAi: a method for evaluating the functions of gene families in Drosophila

Aloisia Schmid et al. Trends Neurosci. 2002 Feb.

Abstract

Individual members of gene families often have partially redundant functions during nervous system development, making conventional genetic analysis problematic. Here we review experiments showing that several genes can be silenced together by injection of double-stranded RNAs into wild-type Drosophila embryos. By dye-labeling single neuroblasts in injected embryos, the effects of multigene silencing on individual CNS axon pathways can now be examined.

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