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. 1998 Jun;4(3):228-230.
doi: 10.3748/wjg.v4.i3.228.

Expression of bcl-2 protein in gastric carcinoma and its significance

Hai-Feng Liu, Wei-Wen Liu, Dian-Chun Fang, Rong-Pu Men

Expression of bcl-2 protein in gastric carcinoma and its significance

Hai-Feng Liu et al. World J Gastroenterol. 1998 Jun.

Abstract

AIM:To further study the role of bcl-2 protein expression in gastric carcinogenesis and tumor progression.METHODS:Using immunohistochemical staining, the bcl-2 protein expression in 50 cases of gastric carcinoma and its relation to clinical status and pathomorphological parameters were observed.RESULTS:Forty-one (82%) cases were positive for bcl-2 protein staining which was located in the cytoplasm and nuclear membrane of tumor cells. The rate of bcl-2 protein expression was not correlated with the patient, sex, tumor size, lymph node status or clinical stages (P > 0.05). It was strongly associated with intestinal-type tumors and poorly differentiated tumors (P < 0.05 andP <0.01).CONCLUSION:Aberrant bcl-2 protein expression appears to be specifically associated with development of intestinal-type gastric carcinoma, bcl-2 protein expression might play an important role in the early development/promotion and phenotypic differentiation of gastric carcinomas, but not in tumor progression.

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Figures

Figure 1
Figure 1
Immunoreactivity of bcl-2 was detected in the cytoplasm of gastric carcinoma cells. SP × 200
See this image and copyright information in PMC

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