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. 1999 Aug;5(4):312-315.
doi: 10.3748/wjg.v5.i4.312.

A study of the ameliorating effects of carnitine on hepatic steatosis induced by total parenteral nutrition in rats

Li-Jian Liang, Xiao-Yu Yin, Shi-Min Luo, Jin-Fang Zheng, Ming-De Lu, Jie-Fu Huang

A study of the ameliorating effects of carnitine on hepatic steatosis induced by total parenteral nutrition in rats

Li-Jian Liang et al. World J Gastroenterol. 1999 Aug.

Abstract

AIM:To investigate the effects of carnitine on ameliorating hepatic steatosis induced by total parenteral nutrition (TPN) in animal model.METHODS: Eighteen normal Wistar rats and 19 cirrhotic Wistar rats induced by carbon tetrachloride were randomly divided into three groups, i.e., free access to food and drink (group A), TPN (group B) and TPN+carnitine (group C) for one week, respectively. Hepatic function, histology and its fat content were determined on the 7th day.RESULTS: Hepatic triglyceride (TG) and cholesterol (CHO) contents were significantly higher in groups B and C than in group A,and significantly lower in group C than in group B in both normal and cirrhotic rats (all P < 0.05). Histopathological examinations revealed that hepatic steatosis was more severe in group B than in group C in both normal and cirrhotic rats.CONCLUSION:Carnitine can ameliorate hepatic steatosis associated with TPN in both non-cirrhotic and cirrhotic rats.

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Figures

Figure 1
Figure 1
Histopathological features of hepatic stea tosis (HE staining, 5 × 10), showing grade + (a), ++++ (b) and ++ (c). (a) Group A2, (b) Group B2, (c) Group C2.
See this image and copyright information in PMC

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