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. 2001 Oct;7(5):657-61.
doi: 10.3748/wjg.v7.i5.657.

Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China

M Su  1 , S M Lu, D P Tian, H Zhao, X Y Li, D R Li, Z C Zheng
Affiliations

Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China

M Su et al. World J Gastroenterol. 2001 Oct.

Abstract

Aim: To study the relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China, which is a unique Littoral high-risk area of esophageal carcinoma in China. The poor communication and transportation in the past has made Chaoshan a relatively closed area and kept its culture and custure of old China thousand years ago.

Methods: Data on age, sex, ABO blood type and X-ray or pathological diagnose of the patients with carcinoma of esophagus or cardia were collected from the Tumor Hospital. First Affiliated Hospital, Second Affiliated Hospital of Shantou University Medical College; and the Central Hospital of Shantou and the Central Hospital of Jieyang. A total of 6685 patients with esophageal carcinoma (EC) and 2955 patients with cardiac cancer (CC) in Chaoshan district were retrospectively assessed for their association with ABO blood groups.

Results: The distribution of ABO blood groups in patients with EC or CC was similar to the normal local population in Chaoshan. However, blood group B in male patients with CC and in the patients with carcinoma in the upper third esophagus was 2.3% and 4.7% higher than the corresponding controls. The relative risk B O was 1.1415 (P<0.05) and 1.2696 (P<0.05), respectively. No relationship was found between ABO blood groups and tumor differentiation.

Conclusion: ABO blood group B is associated with the incidence of CC in male individuals and carcinoma in the upper third esophagus. The distribution of ABO blood groups varies in the different geographical and ethnic groups. As a result, proper controls are very important for such studies.

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Figures

Figure 1
Figure 1
ABO blood group distribution in EC patients (n, %)
Figure 2
Figure 2
Gene frequency of abo blood type in EC and CC patients
Figure 3
Figure 3
Comparison of ABO blood group distribution in different districts in China
See this image and copyright information in PMC

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