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Review
. 2001 Oct 20;131(41-42):595-602.
doi: 10.4414/smw.2001.09751.

Procalcitonin: how a hormone became a marker and mediator of sepsis

B Müller  1 , K L Becker
Affiliations
Free article
Review

Procalcitonin: how a hormone became a marker and mediator of sepsis

B Müller et al. Swiss Med Wkly. .
Free article

Abstract

Calcitonin was discovered in the early 1960s [1], at which time it was assumed to be a single hormone with a yet-to-be-determined role in human physiology. Since then it has been found to be only one entity among a large array of related circulating peptides, at least one of which has a pivotal role in the host response to microbial infections [2, 3]. The aim of this review is to describe this metamorphosis of an endocrine hormone to a new class of hormokine mediators in infectious diseases.

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