doi: 10.1111/j.1365-2133.1975.tb03152.x.
Effects of intensive application of retinoic acid on human skin
- PMID: 1182085
- DOI: 10.1111/j.1365-2133.1975.tb03152.x
Item in Clipboard
Effects of intensive application of retinoic acid on human skin
Br J Dermatol.
1975 Jun.
Abstract
The daily application of 0-3% retinoic acid to the back produced an acute irritant dermatitis which resolved to a near-normal clinical appearance within 40 days despite continued daily exposure. Hardened skin was markedly altered physiologically. The responses to DMSO, histamine and the histamine liberator, compound 48/80, were sharply enhanced. This reflected enhanced permeability resulting from reduction of the horny layer to less than one-half its normal thickness. Phototoxic and irritant substances produced exaggerated reactions owing to greater penetration. A paradoxical decrease in delayed sinsitivity to streptodornase-streptokinase was attributed to enhanced clearance of the antigen.
Similar articles
-
Allergic contact dermatitis to All-trans-retinoic acid; epicutaneous and leukocyte migration inhibition testing.Contact Dermatitis. 1975 Oct;1(5):306-10. doi: 10.1111/j.1600-0536.1975.tb05443.x. Contact Dermatitis. 1975. PMID: 1235282
-
Allergic contact response to vitamin A acid.Contact Dermatitis. 1976 Aug;2(4):212-7. doi: 10.1111/j.1600-0536.1976.tb03029.x. Contact Dermatitis. 1976. PMID: 139276
-
[Skin responses to histamine and compound 48/80 in cases with refractory atopic dermatitis].Nihon Hifuka Gakkai Zasshi. 1988 Apr;98(4):481-3. Nihon Hifuka Gakkai Zasshi. 1988. PMID: 3230656 Japanese. No abstract available.
-
[Skin reactivity and time of reconstitution of the cutaneous histamine content after depletion with histamine-liberator in the aged].G Gerontol. 1966 Aug;14(8):705-14. G Gerontol. 1966. PMID: 5989217 Italian. No abstract available.
-
Non-immunologic contact urticaria.Acta Derm Venereol Suppl (Stockh). 1980;Suppl 91:1-49. doi: 10.2340/0001555591149. Acta Derm Venereol Suppl (Stockh). 1980. PMID: 6106992 No abstract available.
Cited by
-
Current status of topical tretinoin in the treatment of photoaged skin.Drugs Aging. 1992 Jan-Feb;2(1):7-13. doi: 10.2165/00002512-199202010-00002. Drugs Aging. 1992. PMID: 1554975 Review.
-
Influences of retinoic acid and retinoid on skin metabolism. Investigations of oxygen consumption and enzymatic activities of human skin.Arch Dermatol Res (1975). 1976 Oct 27;256(3):247-54. doi: 10.1007/BF00572489. Arch Dermatol Res (1975). 1976. PMID: 984876
-
Vitamin A acid: a review of its pharmacological properties and therapeutic use in the topical treatment of acne vulgaris.Drugs. 1977 Dec;14(6):401-19. doi: 10.2165/00003495-197714060-00001. Drugs. 1977. PMID: 145940 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
