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. 2002 Feb 7;4(3):419-21.
doi: 10.1021/ol017122w.

Diastereoselective synthesis of protected syn 1,3-diols: preparation of the C16-C24 portion of Dolabelides

Laurence Grimaud  1 , Romain de Mesmay, Joëlle Prunet
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Diastereoselective synthesis of protected syn 1,3-diols: preparation of the C16-C24 portion of Dolabelides

Laurence Grimaud et al. Org Lett. .

Abstract

We have designed a new method to make synthons encompassing a protected syn 1,3-diol motif and an aldehyde alpha to the 1,3-dioxane ring. An additional stereocenter was also created, potentially leading to stereochemically defined 1,2,4-triols. This method was successfully applied to the synthesis of the C16-C24 portion of Dolabelides.

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