Familial oligoasthenoteratozoospermia: evidence of autosomal dominant inheritance with sex-limited expression

Abstract

Objective: To report the familial occurrence of severe oligoasthenoteratozoospermia in a man and five male relatives related through their mothers.

Design: Case report.

Setting: University medical center.

Patient(s): Six affected family members.

Main outcome measure(s): Blood and semen samples were collected from all affected males and some of their healthy male relatives. Pedigree analysis and exclusion of X-linked disorder were done.

Result(s): Analysis suggested that familial nonsyndromic male factor infertility was present.

Conclusion(s): The family described in this report suggests the existence of an autosomal dominant trait of male infertility with sex-limited expression.