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Review
. 2002 Feb:17:32-7.
doi: 10.1152/physiologyonline.2002.17.1.32.

From funny current to HCN channels: 20 years of excitation

E A Accili  1 , C Proenza, M Baruscotti, D DiFrancesco
Affiliations
Review

From funny current to HCN channels: 20 years of excitation

E A Accili et al. News Physiol Sci. 2002 Feb.

Abstract

The "funny" (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K(+) and Na(+), modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties.

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