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. 2002 Feb;8(2):166-70.
doi: 10.1038/nm0202-166.

IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages

Luzia H Carvalho  1 , Gen-Ichiro Sano, Julius C R Hafalla, Alexandre Morrot, Maria A Curotto de Lafaille, Fidel Zavala
Affiliations

IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages

Luzia H Carvalho et al. Nat Med. 2002 Feb.

Abstract

CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days after immunization. However, this response fails to develop further and is reduced by more than 90%, compared to that observed in the presence of CD4+ T cells. We report here that interleukin-4 (IL-4) secreted by CD4+ T cells is essential to the full development of this CD8+ T cell response. This is the first demonstration that IL-4 is a mediator of CD4/CD8 cross-talk leading to the development of immunity against an infectious pathogen.

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