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. 1975;5(1):59-66.
doi: 10.1016/s0006-3061(00)80221-5.

DNA-platinum interactions in vitro with trans- and cis-Pt(NH3)2Cl2

J P Macquet, T Theophanides

DNA-platinum interactions in vitro with trans- and cis-Pt(NH3)2Cl2

J P Macquet et al. Bioinorg Chem. 1975.

Abstract

In the present study the nature and the hydrolysis of DNA-Pt complexes with the platinum compounds, [Pt(dien)Cl]Cl, trans- and cis-Pt(NH3)2Cl2, using potentiometric chloride determinations, have been investigated. The trans-Pt(NH3)2Cl2 and the [Pt(dien)Cl]Cl react with the GC planes at the N7(G) sites, while the cis-Pt(NH3)2Cl2 compound reacts with the GC planes and forms a chelate by using the N7(G) and O6(G) sites. The complex is a specific 1:1 Pt:DNA adduct. The platinum atom in cis-Pt(NH3)2Cl2 liberates both chlorine atoms on chelation. A mechanism for the in vivo antitumor activity of the cis-Pt(NH3)2Cl2 is proposed and the structure activity relationship is discussed.

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