Comparative Study
doi: 10.1016/s0300-9084(75)80139-8.
Kinetic amplification of enzyme discrimination
- PMID: 1182215
- DOI: 10.1016/s0300-9084(75)80139-8
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Comparative Study
Kinetic amplification of enzyme discrimination
Biochimie.
1975.
Abstract
The dependence of the accuracy of enzymatic systems on the mechanism of the catalyzed reaction is investigated, using a probabilistic approach. Certain mechanisms of reaction, involving a delay in one of the steps act as kinetic amplifiers of molecular discriminations. The relationship between our scheme for a delayed reaction [1] and Hopfield's scheme [i] is discussed.
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