Synthesis of some new triazoles as potential antifungal agents

Abstract

The rise in the incidence of fungal infections over the past two decades, particularly those caused by opportunistic pathogens in immune-compromised patients, has strengthened the need for new antifungal drugs. New triazole derivatives were synthesized and evaluated for their in-vitro antifungal activities against three species of fungi. Most of the prepared compounds showed good antifungal activity. Three compounds exhibited pronounced activity against Cryptococcus neoformans with MIC less than 12.5 g/ml.