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Review
. 2002 Jan;3(1):11-20.
doi: 10.1038/nrm714.

Sibling rivalry in the E2F family

Jeffrey M Trimarchi  1 , Jacqueline A Lees
Affiliations
Review

Sibling rivalry in the E2F family

Jeffrey M Trimarchi et al. Nat Rev Mol Cell Biol. 2002 Jan.

Abstract

The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me-pull-you' regulation, and what are its biological consequences?

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