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. 2002 Mar 1;34(5):708-10.
doi: 10.1086/338716. Epub 2002 Jan 25.

Cross-linked fibrin in the nasal fluid of patients with the common cold

Birgit Winther  1 , Jack M Gwaltney Jr, John E Humphries, J Owen Hendley
Affiliations

Cross-linked fibrin in the nasal fluid of patients with the common cold

Birgit Winther et al. Clin Infect Dis. .

Abstract

To determine whether adherent material found on the walls of the paranasal sinuses during common colds might be fibrin clot, we examined the nasal fluid (a surrogate for sinus secretion) of 11 young adults with experimentally induced rhinovirus colds and that of 4 control subjects for the presence of fibrin. The mean concentration (+/- the standard error) of insoluble fibrin (measured as D-dimer) in subjects with rhinovirus colds increased from a baseline level of 0.8+/-0.4 microgram/mL to a peak of 2.4+/-0.7 microgram/mL (P=.0008) on day 4 after inoculation of the virus, but the fibrin concentration remained at baseline levels in the 4 uninfected control subjects.

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Figures

Figure 1
Figure 1
CT scan of the sinuses of an adult with viral rhinosinusitis (i.e., the common cold). There is occlusion of the infundibula (arrowheads) and the material adherent to the walls of the maxillary sinuses (arrows). One large air bubble and several small air bubbles are in the material in the left sinus cavity. (Figure reprinted with permission from the New England Journal of Medicine.)
Figure 2
Figure 2
Mean concentrations (±SE) of fibrinogen and fibrinogen degradation products (FDP; A) and of D-dimer (cross-linked fibrin; B) in nasal wash samples obtained from study volunteers who were inoculated with rhinovirus.
Figure 3
Figure 3
Relative concentrations of fibrinogen/fibrinogen degradation products (FDP) and albumin concentrations in nasal wash samples.
See this image and copyright information in PMC

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