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. 2002 Jan;25(1):125-7.
doi: 10.1248/bpb.25.125.

(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase

Sang Hyun Sung  1 , So Young Kang, Ki Yong Lee, Mi Jung Park, Jeong Hun Kim, Jong Hee Park, Young Chul Kim, Jinwoong Kim, Young Choong Kim
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Free article

(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase

Sang Hyun Sung et al. Biol Pharm Bull. 2002 Jan.
Free article

Abstract

In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of 1 and 2 were 2.0 and 115.8 microM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.

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