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. 2002 Jan;25(1):145-6.
doi: 10.1248/bpb.25.145.

Estrogenic activities of chemicals in diesel exhaust particles

Yoki Mori  1 , Shinji Taneda, Hideyuki Hayashi, Akiyo Sakushima, Kazuyuki Kamata, Akira K Suzuki, Shin Yoshino, Masakatsu Sakata, Masaru Sagai, Koh-ichi Seki
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Free article

Estrogenic activities of chemicals in diesel exhaust particles

Yoki Mori et al. Biol Pharm Bull. 2002 Jan.
Free article

Abstract

In a previous study, we focused on estrogenic activity of the hexane extract of diesel exhaust particles (DEP). The extract of hexane was first fractionated to acidic, phenolic and neutral portions according to their chemical properties, of which the neutral fraction was fractionated by column chromatography on silica gel. The chemical structures of compounds in these fractions were then analyzed. It was found that the neutral fraction of the hexane extract of DEP contains dibenzothiophene derivatives, one of which, 4,6-dimethyldibenzothiophene, possesses estrogenic activity.

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