Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Feb 1;22(3):629-34.
doi: 10.1523/JNEUROSCI.22-03-00629.2002.

Neurogenesis in adult subventricular zone

Arturo Alvarez-Buylla  1 , Jose Manuel Garcia-Verdugo
Affiliations
Review

Neurogenesis in adult subventricular zone

Arturo Alvarez-Buylla et al. J Neurosci. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
The SVZ–OB system. Schematic sagittal view of the adult rodent brain with the OB to the left and the cerebellum (CB) to the right. The SVZ is along the lateral wall of the lateral ventricle (LV, blue). New neurons are constantly produced throughout the SVZ. The young neurons (A cells) (Fig. 3) become aligned into long chains (red lines) (Fig. 2) that form a complex network of interconnected paths throughout the SVZ. Many of these chains in the anterior SVZ connect with the RMS, which leads young neurons into the core of the olfactory bulb. Within the olfactory bulb, cells disperse radially (dotted lines) as individual cells and complete their differentiation into granule and periglomerular interneurons.NC, Neocortex; cc, corpus callosum.
Fig. 2.
Fig. 2.
Chain migration. Young neurons within the SVZ network and in the RMS migrate along each other to form long chains. Chains of migrating cells (red) are ensheathed by glial cells (blue) that have astrocytic characteristics, including dense bundles of GFAP-containing intermediate filaments and endings on blood vessel (below). Two chains are illustrated here. In the bottom chain only some of the astrocytes have been drawn to illustrate the tight organization of A cell into chains. The intracellular characteristics of some of the B cells (light blue) and A cells (yellow) are illustrated. An A cell in mitosis is illustrated in thebottom chain to the right.
Fig. 3.
Fig. 3.
Organization and lineage in the SVZ.Left, Cross section of the anterior rodent brain indicating the location of the SVZ on the lateral wall of the LV. On the right is the cellular composition and organization of the SVZ. Chains of young neurons (A cells, red) are surrounded by B cells (blue) that have astrocytic characteristics and form tube-like structures. Clusters of highly proliferative C cells are associated with the chains of A cells. Ependymal (E) cells form an epithelial layer that separates the SVZ from the ventricle (LV). B cells generate transient amplifying C cells that generate the A cells (top). Bottom left, BMPs inhibit neurogenesis and favor glial differentiation (blue). Noggin secreted by ependymal cells binds BMPs and releases some B cells to become neurogenic and produce C (green) and A (red) cells.
See this image and copyright information in PMC

References

    1. Altman J. Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb. J Comp Neurol. 1969;137:433–458. - PubMed
    1. Alvarez-Buylla A, Kirn JR, Nottebohm F. Birth of projection neurons in adult avian brain may be related to perceptual or motor learning. Science. 1990a;249:1444–1446. - PubMed
    1. Alvarez-Buylla A, Theelen M, Nottebohm F. Proliferation “hot spots” in adult avian ventricular zone reveal radial cell division. Neuron. 1990b;5:101–109. - PubMed
    1. Alvarez-Buylla A, Garcia-Verdugo JM, Tramontin AD. A unified hypothesis on the lineage of neural stem cells. Nat Rev Neurosci. 2001;2:287–293. - PubMed
    1. Barnea A, Nottebohm F. Seasonal recruitment of hippocampal neurons in adult free-ranging black-capped chickadees. Proc Natl Acad Sci USA. 1994;91:11217–11221. - PMC - PubMed

Publication types

LinkOut - more resources