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Review

. 2002 Feb 5;99(3):1104-6.

doi: 10.1073/pnas.042004099.

The methylator meets the terminator

Steven Clarke¹

Affiliations

PMID: 11830650
PMCID: PMC122150
DOI: 10.1073/pnas.042004099

Review

The methylator meets the terminator

Steven Clarke. Proc Natl Acad Sci U S A. 2002.

. 2002 Feb 5;99(3):1104-6.

doi: 10.1073/pnas.042004099.

Author

Steven Clarke¹

Affiliation

¹ Department of Chemistry and Biochemistry, and the Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA. clarke@mbi.ucla.edu

PMID: 11830650
PMCID: PMC122150
DOI: 10.1073/pnas.042004099

No abstract available

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Figures

Figure 1
Methyltransferase reactions that result in the formation of N-methylated amides in protein-bound glutamine and asparagine residues. The N-5 and N-4 designations refer to the number of the carboxyl carbon atom that the methyl amine is attached to; heavy lines show the polypeptide backbone. AdoMet, S-adenosyl-l-methionine; AdoHcy, S-adenosyl-l-homocysteine. HemK catalyzes the methylation of RFs; PrmB catalyzes the methylation of the L3 ribosomal protein. See text for references.

See this image and copyright information in PMC

Comment on

HemK, a class of protein methyl transferase with similarity to DNA methyl transferases, methylates polypeptide chain release factors, and hemK knockout induces defects in translational termination.
Nakahigashi K, Kubo N, Narita S, Shimaoka T, Goto S, Oshima T, Mori H, Maeda M, Wada C, Inokuchi H. Nakahigashi K, et al. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1473-8. doi: 10.1073/pnas.032488499. Epub 2002 Jan 22. Proc Natl Acad Sci U S A. 2002. PMID: 11805295 Free PMC article.

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References

1. Nakahigashi K, Kubo N, Narita S-I, Shimaoka T, Goto S, Oshima T, Mori H, Maeda M, Wada C, Inokuchi H. Proc Natl Acad Sci USA. 2002;99:1473–1478. - PMC - PubMed
1. Nakayashiki T, Nishimura K, Inokuchi H. Gene. 1995;153:67–70. - PubMed
1. Elliott T. J Bacteriol. 1989;171:3948–3960. - PMC - PubMed
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