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Review
. 2002 Jan 25;108(2):145-52.
doi: 10.1016/s0092-8674(02)00622-0.

Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models

Allan Balmain  1
Affiliations
Free article
Review

Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models

Allan Balmain. Cell. .
Free article

Abstract

Cancer directly affects at least one-third of the human population, but the inherited genetic determinants of cancer risk remain largely unknown. Mouse models of human cancer are helping us to understand this disease as a complex genetic trait and thus to identify the multiple genetic variant alleles involved in pathways that affect individual cancer susceptibility.

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