Review
doi: 10.1016/s0092-8674(02)00626-8.
The role of PML in tumor suppression
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- PMID: 11832207
- DOI: 10.1016/s0092-8674(02)00626-8
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Review
The role of PML in tumor suppression
Cell.
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Free article
Abstract
The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular structure. PML controls apoptosis, cell proliferation, and senescence. Here, we review the current understanding of its role in tumor suppression.
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