[HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway]
[Article in
French]
Affiliations
- PMID: 11833470
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[HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway]
[Article in
French]
J Soc Biol.
2001.
Erratum in
- J Soc Biol. 2005;199(1):2 p following 77. Yamina, B [corrected to Bennasser, Y]; Xavier, C [corrected to Contreras, X]; Marc, M [corrected to Moreau, M]; Catherine, L [corrected to Le Clerc, C]; Abdallah, B [corrected to Badou, A]
Abstract
In asymptomatic patients infected by HIV-1, the level of IL-10, a cytokine with immunosuppressive activity, is associated with the course of HIV infection towards AIDS. We show that HIV-1 Tat, a viral protein secreted by infected cells, induces IL-10 production by human peripheral blood monocytes. The analysis of the signal transduction pathways strongly suggests that the protein kinase C may play an essential role in this induction. Stimulation by Tat induces nuclear translocation of the transcription factor NFkB the activation of which seems to be necessary for IL-10 production. Using microspectrofluorimetry and confocal microscopy, we also show that Tat induces a calcium influx.
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