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Review
. 2002 Feb 8;295(5557):1005-9.
doi: 10.1126/science.1068660.

A bioartificial liver--state of the art

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Review

A bioartificial liver--state of the art

Alastair J Strain et al. Science. .

Abstract

End-stage liver disease is treated by liver transplantation, but donor organ shortages remain a serious problem. This has prompted the design of bioartificial liver devices to "bridge" patients until they either recover or receive a liver transplant. In these devices, patient plasma is circulated extracorporeally through a bioreactor that houses liver cells (hepatocytes) sandwiched between artificial plates or capillaries.

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