[Effect of prostaglandins F2alpha and E1 on systemic and regional hemodynamics]

Abstract

In experiments with anesthetized female-rats the influence of intravenous prostaglandins F2alpha (40 mg/kg) and Ei (10 mg/kg) on the cardiac output (by the method of dye dilution) and on the blood flow distribution among organs and tissues (by the method of Rb86 distribution) was studied. Prostaglandin F2alpha increased the arterial pressure, cardiac output along with the volume of the circulating plasma and reduced the total peripheral resistance. The hypertensive effect of prostaglandin F 2alpha is, under the circumstances, conditioned by the increased cardiac output and this substance is also instrumental in augmenting the proportion of the blood flow going to the digestive tract, skeletal muscles and, at the same time, in reducing its share flowing to the liver, spleen, skin and the uterus. Prostaglandin E1 reduced the blood pressure and total peripheral resistance and raised the cardiac output. The hypotensive effec of prostaglandin Ei is due to the fall of the total peripheral resistance. This compound tends to increase the part of the cardiac output that goes to supply the intesine, liver, lungs, myocardium and skeletal muscles and cuts down that part which caters for the stomach and kidneys.