SACS--self-maintaining database of antibody crystal structure information

Abstract

Motivation: The rapid increase in the number of structures in the Protein Databank (PDB) makes it difficult to find all structures in a given protein class. Automatically-maintained web-based summaries are one solution to this problem.

Results: Summary of Antibody Crystal Structures (SACS), a self-maintaining web-site containing summary information on antibody structures in the PDB, is described. Mirrored PDB data are processed automatically using a Make-based system to identify new antibody structures. The PDB header records and sequence data are then parsed to identify a number of features of the structure and the data are stored using eXtensible Markup Language (XML). eXtensible Stylesheet Language: Transformations (XSLT), a new style sheet language for XML, is used to generate Hypertext Markup Language (HTML) pages containing either a one-line summary of every structure or a more detailed page describing a single antibody.