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Review
. 2002 Feb;12(1):89-97.
doi: 10.1016/s0959-440x(02)00294-4.

Multisubunit RNA polymerases

Patrick Cramer  1
Affiliations
Review

Multisubunit RNA polymerases

Patrick Cramer. Curr Opin Struct Biol. 2002 Feb.

Abstract

Transcription of the genetic information in all cells is carried out by multisubunit RNA polymerases (RNAPs). Comparison of the crystal structures of a bacterial and a eukaryotic RNAP reveals a conserved core that comprises the active site and a multifunctional clamp. Together with a further structure of eukaryotic RNAP bound to DNA and RNA, these results elucidate many aspects of the transcription mechanism, including initiation, elongation, nucleotide addition, processivity and proofreading.

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