Review
doi: 10.1016/s0959-440x(02)00296-8.
Eukaryotic transcription factors
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- PMID: 11839497
- DOI: 10.1016/s0959-440x(02)00296-8
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Review
Eukaryotic transcription factors
Curr Opin Struct Biol.
2002 Feb.
Abstract
Recently determined high-resolution structures of eukaryotic transcription factors have illuminated the enzymatic mechanism underlying transcription. Progress has been made in characterising protein-protein interactions between negative cofactors and general transcription factors, and between transrepression domains and corepressors. Structures of sequence-specific transcription factors have revealed further versatility in the mode of interaction with DNA and several have provided new insights into the molecular basis of human disease.
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