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. 2001 Dec 20;20(58):8308-16.
doi: 10.1038/sj.onc.1205091.

The regulation and function of the Id proteins in lymphocyte development

R Rivera  1 , C Murre
Affiliations

The regulation and function of the Id proteins in lymphocyte development

R Rivera et al. Oncogene. .

Abstract

Helix-loop-helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation, survival, proliferation, and differentiation. E-proteins are negatively regulated by another class of HLH proteins known as the Id proteins. The Id proteins function as dominant negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here we discuss the function and regulation of the Id proteins in lymphocyte development.

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