Ralstonia pickettii bacteraemia in a cord blood transplant recipient

Abstract

A seven-year old boy with acute lymphoblastic leukemia underwent an HLA mismatched cord blood transplant. He developed grade 2 mucositis requiring morphine infusion and grade 3-4 hyperacute graft-versus-host disease affecting the skin, gastrointestinal tract, and liver requiring pulse methylprednisolone. On days 21, 23, and 24 post-transplant, blood culture obtained through the central line and periphery were positive for Ralstonia pickettii. The same strain (with the same biochemical profile and antibiotic susceptibility pattern) was also recovered from surveillance throat swab cultures from day 11 to day 24 and surveillance rectal swab cultures from day 16 to day 24. The patient responded to intravenous cefoperazone/sulbactam and ciprofloxacin and blood culture became negative 3 days after commencement of the antibiotics. Although R. pickettii is of low virulence and is a frequent contaminant of blood cultures, it should not be overlooked when it is repeatedly recovered from sterile body fluids, especially in immunocompromised hosts.