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Comparative Study
. 2002 Jan;116(1):151-4.
doi: 10.1046/j.1365-2141.2002.03229.x.

Evolution of myelodysplastic syndrome and acute myelogenous leukaemia in children with hepatitis-associated aplastic anaemia

Akira Ohara  1 , Seiji Kojima, Jun Okamura, Hiroko Inada, Hisato Kigasawa, Shigeyoshi Hibi, Ichiro Tsukimoto; Aplastic Anaemia Committee of the Japanese Society of Pediatric Haematology
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Comparative Study

Evolution of myelodysplastic syndrome and acute myelogenous leukaemia in children with hepatitis-associated aplastic anaemia

Akira Ohara et al. Br J Haematol. 2002 Jan.

Abstract

In hepatitis-associated aplastic anaemia (HAA), an immune-mediated mechanism is solely responsible for the development of pancytopenia. We retrospectively analysed the clinical outcome of 61 children with HAA, diagnosed between 1988 and 1996. Of 61 patients, 41 did not receive bone marrow transplantation (BMT) and their survival rate at 7 years was 61.4 +/- 9.3%(+/- SE). Five of these 41 patients developed myelodysplastic syndrome (MDS) or acute myelogenous leukaemia (AML) 7-57 months after the diagnosis of HAA. The incidence of MDS/AML in severe HAA patients who did not receive BMT (n = 30, 27.0 +/- 10.8%) appeared to be similar to that of severe idiopathic AA patients (n = 155, 14.7 +/- 3.7%) treated in the same period.

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