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Case Reports
. 2001 Nov;51(11):874-8.
doi: 10.1046/j.1440-1827.2001.01295.x.

Primary neuroendocrine carcinoma of the liver: an autopsy case

G Kaya  1 , C Pasche, M C Osterheld, P Chaubert, C Fontolliet
Affiliations
Case Reports

Primary neuroendocrine carcinoma of the liver: an autopsy case

G Kaya et al. Pathol Int. 2001 Nov.

Abstract

An autopsy case of primary hepatic neuroendocrine carcinoma is described. A 72-year-old man had a large tumor mass measuring 22 cm in its greatest diameter and localized to the right, left and caudal lobes of the non-cirrhotic liver. Microscopically, the tumor was composed of middle-sized pleomorphic cells organized in ribbons or trabeculae, with scanty intersecting fibrous septae. Immunohistochemically, the tumor cells were positive for multikeratin C11, chromogranin A and synaptophysin. The patient also had metastases in the bone marrow. No alternative primary source of endocrine tumor was detected. The patient died 4 days after presentation.

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