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. 2002 Feb 25;12(4):629-32.
doi: 10.1016/s0960-894x(01)00813-7.

A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor

Satoshi Sunami  1 , Mitsuru Ohkubo, Takeshi Sagara, Jun Ono, Shuichi Asahi, Seita Koito, Hajime Morishima
Affiliations

A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor

Satoshi Sunami et al. Bioorg Med Chem Lett. .

Abstract

Replacement of the thiol groups in 1, a potent and highly selective Candida albicans GGTase I inhibitor discovered through screening, with an imidazole ring was achieved by using solid phase synthesis. A non-thiol compound, 7, was found as a representative of a new class of potent C. albicans GGTase I inhibitor with high selectivity against human GGTase I.

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