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. 2002 Feb 25;12(4):675-6.
doi: 10.1016/s0960-894x(01)00830-7.

Induction of apoptosis in HL-60 cells by photochemically generated hydroxyl radicals

Sakiko Haruna  1 , Rie Kuroi, Kazumi Kajiwara, Ryoko Hashimoto, Seiichi Matsugo, Sadako Tokumaru, Shosuke Kojo
Affiliations

Induction of apoptosis in HL-60 cells by photochemically generated hydroxyl radicals

Sakiko Haruna et al. Bioorg Med Chem Lett. .

Abstract

Reactive oxygen species (ROS), especially hydroxyl radicals are postulated to mediate apoptosis of the cell. Here we demonstrate that hydroxyl radicals generated selectively by photolysis of a photo-Fenton reagent, N,N'-bis(2-hydroperoxy-2-methoxyethyl)-1,4,5,8-naphthaldiimide (NP-III), induce apoptosis in HL-60 (human promyelocytic leukemia) cells involving the activation of caspase-3.

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