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. 1979 Dec;76(12):6376-80.
doi: 10.1073/pnas.76.12.6376.

Reorganization of actin in platelets stimulated by thrombin as measured by the DNase I inhibition assay

L Carlsson, F Markey, I Blikstad, T Persson, U Lindberg

Reorganization of actin in platelets stimulated by thrombin as measured by the DNase I inhibition assay

L Carlsson et al. Proc Natl Acad Sci U S A. 1979 Dec.

Abstract

The effect of thrombin stimulation on actin organization in human platelets has been analyzed by using the DNase I inhibition assay, which is selective for unpolymerized and filamentous actin. The results provide biochemical evidence for the suggestion that stimulation leads to rapid polymerization of actin. The measurements also reveal changes in the polymerization state of actin occurring after cell lysis. These changes are influenced by the concentration of free calcium in the extracts.

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