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. 1979 Nov;23(5):887-90.
doi: 10.1016/0031-9384(79)90196-3.

Cholecystokinin suppresses sham feeding in the rhesus monkey

J D Falasco, G P Smith, J Gibbs

Cholecystokinin suppresses sham feeding in the rhesus monkey

J D Falasco et al. Physiol Behav. 1979 Nov.

Abstract

The satiety effect of slow intravenous infusions of impure cholecystokinin (CCK) was investigated in 5 rhesus monkeys during sham feeding. CCK suppressed sham feeding. The dose for 50% inhibition of sham feeding was about 10 U/kg-hr; 20 U/kg-hr abolished sham feeding. No dose produced retching, vomiting, diarrhea or other behavioral signs of toxicity. These results demonstrate the potency of CCK for inhibiting feeding in the monkey when gastric, intestinal and postabsorptive mechanisms are not activated by ingested food.

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