Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Mar 15;295(5562):2073-6.
doi: 10.1126/science.1067554. Epub 2002 Feb 14.

The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance

Cristina Azevedo  1 , Ari Sadanandom, Katsumi Kitagawa, Andreas Freialdenhoven, Ken Shirasu, Paul Schulze-Lefert
Affiliations

The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance

Cristina Azevedo et al. Science. .

Abstract

Plant disease resistance (R) genes trigger innate immune responses upon pathogen attack. RAR1 is an early convergence point in a signaling pathway engaged by multiple R genes. Here, we show that RAR1 interacts with plant orthologs of the yeast protein SGT1, an essential regulator in the cell cycle. Silencing the barley gene Sgt1 reveals its role in R gene-triggered, Rar1-dependent disease resistance. SGT1 associates with SKP1 and CUL1, subunits of the SCF (Skp1-Cullin-F-box) ubiquitin ligase complex. Furthermore, the RAR1-SGT1 complex also interacts with two COP9 signalosome components. The interactions among RAR1, SGT1, SCF, and signalosome subunits indicate a link between disease resistance and ubiquitination.

PubMed Disclaimer

Comment in

  • Plant biology. Resisting attack.
    Nishimura M, Somerville S. Nishimura M, et al. Science. 2002 Mar 15;295(5562):2032-3. doi: 10.1126/science.1070443. Science. 2002. PMID: 11896264 No abstract available.

Publication types

MeSH terms

Substances