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Review
. 2001 Dec;12(6):626-31.
doi: 10.1016/s0958-1669(01)00271-3.

In vivo drug target discovery: identifying the best targets from the genome

D W Walke  1 , C Han, J Shaw, E Wann, B Zambrowicz, A Sands
Affiliations
Review

In vivo drug target discovery: identifying the best targets from the genome

D W Walke et al. Curr Opin Biotechnol. 2001 Dec.

Abstract

A vast number of genes of unknown function threaten to clog drug discovery pipelines. To develop therapeutic products from novel genomic targets, it will be necessary to correlate biology with gene sequence information. Industrialized mouse reverse genetics is being used to determine gene function in the context of mammalian physiology and to identify the best targets for drug development.

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