Review
doi: 10.1016/s0958-1669(01)00272-5.
Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins
Affiliations
- PMID: 11849947
- DOI: 10.1016/s0958-1669(01)00272-5
Item in Clipboard
Review
Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins
Curr Opin Biotechnol.
2001 Dec.
Abstract
Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.
Similar articles
-
Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies.Acc Chem Res. 2014 Aug 19;47(8):2309-18. doi: 10.1021/ar500039w. Epub 2014 May 30. Acc Chem Res. 2014. PMID: 24877793 Free PMC article.
-
Design of polydactyl zinc-finger proteins for unique addressing within complex genomes.Proc Natl Acad Sci U S A. 1997 May 27;94(11):5525-30. doi: 10.1073/pnas.94.11.5525. Proc Natl Acad Sci U S A. 1997. PMID: 9159105 Free PMC article.
-
Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins.Biochemistry. 2003 Feb 25;42(7):2137-48. doi: 10.1021/bi026806o. Biochemistry. 2003. PMID: 12590603
-
Artificial zinc finger peptides: creation, DNA recognition, and gene regulation.J Inorg Biochem. 2000 Nov;82(1-4):57-63. doi: 10.1016/s0162-0134(00)00154-9. J Inorg Biochem. 2000. PMID: 11132639 Review.
-
Artificial zinc finger DNA binding domains: versatile tools for genome engineering and modulation of gene expression.J Cell Biochem. 2015 Nov;116(11):2435-44. doi: 10.1002/jcb.25226. J Cell Biochem. 2015. PMID: 25989233 Free PMC article. Review.
Cited by
-
Balancing between affinity and speed in target DNA search by zinc-finger proteins via modulation of dynamic conformational ensemble.Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5142-9. doi: 10.1073/pnas.1507726112. Epub 2015 Aug 31. Proc Natl Acad Sci U S A. 2015. PMID: 26324943 Free PMC article.
-
Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo. Fourth in review series on chromatin dynamics.EMBO Rep. 2002 Jul;3(7):610-5. doi: 10.1093/embo-reports/kvf140. EMBO Rep. 2002. PMID: 12101091 Free PMC article. Review.
-
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities.Nucleic Acids Res. 2003 Nov 1;31(21):6064-78. doi: 10.1093/nar/gkg815. Nucleic Acids Res. 2003. PMID: 14576293 Free PMC article. Review.
-
Toward a functional annotation of the human genome using artificial transcription factors.Genome Res. 2003 Dec;13(12):2708-16. doi: 10.1101/gr.1397903. Genome Res. 2003. PMID: 14656973 Free PMC article.
-
From Bioengineering to CRISPR/Cas9 - A Personal Retrospective of 20 Years of Research in Programmable Genome Targeting.Front Genet. 2018 Jan 26;9:5. doi: 10.3389/fgene.2018.00005. eCollection 2018. Front Genet. 2018. PMID: 29434619 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
