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Comment
. 2002 Mar;46(3):938-9.
doi: 10.1128/AAC.46.3.938-939.2002.

Importance of species selection in arrythmogenic models of Q-T interval prolongation

Jeff S McDermott, Heinz J Salmen, Bryan F Cox, Gary A Gintant
Comment

Importance of species selection in arrythmogenic models of Q-T interval prolongation

Jeff S McDermott et al. Antimicrob Agents Chemother. 2002 Mar.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Effects of select drugs on rat ventricular repolarization. (A and B) Action potential traces from rat papillary muscle preparations. In each panel, pairs of superimposed traces show effects obtained during continuous recordings before and after drug exposure. Panel A highlights the lack of effect of E-4031 (1.0 μM) on APD, while panel B shows prominent prolongation of APD with erythromycin (3.6 μM) exposure. (C) Effects of erythromycin (Ery.), E-4031, and dofetilide on APD. Drugs are arranged on the abscissa in the order of increasing potency for blocking native iKr. While erythromycin significantly prolongs the APD at a concentration far below that which blocks iKr (IC50 = 100 μM [7]), high concentrations of iKr-blocking agents E-4031 and dofetilide (2.5-fold above the 50% inhibitory concentration for blocking native iKr [1, 5]) minimally prolong repolarization. n = 5 per group; the data are means ± standard errors of the means. Statistical significance was defined as P < 0.05 (∗) (paired t tests).
See this image and copyright information in PMC

Comment on

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